Rabbit anti-Human IFT74 Polyclonal Antibody

Uniprot Id

Q96LB3

Target Species

Human

Target Name

IFT74

Target Full Name

Intraflagellar transport protein 74 homolog

Target Function

Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.

Target Involvement

Bardet-Biedl syndrome 20 (BBS20)

Target Subcellular Location

Cell projection, cilium. Cytoplasmic vesicle. Note=Localizes along primary cilia at interphase and around the basal body/centriole at interphase and mitosis.

Target Protein Families

IFT74 family

Target Tissue Specificity

Highly expressed in adult and fetal kidney and expressed at lower level in adult heart, placenta, lung, liver and pancreas, and in fetal heart, lung and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thym

Target Synonyms

intraflagellar transport 74, Chlamydomonas, homolog of; Capillary morphogenesis gene 1 protein; Capillary morphogenesis protein 1; Ccdc2; CMG 1; CMG-1; Coiled-coil domain containing 2; Coiled-coil domain-containing protein 2; IFT74; IFT74_HUMAN; intraflagellar transport 74 homolog (Chlamydomonas); intraflagellar transport 74 homolog; Intraflagellar transport protein 74 homolog

Target Background

This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome.