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The antibody against INPP5A was raised in rabbit using the Recombinant Human Type I inositol 1,4,5-trisphosphate 5-phosphatase protein (1-409AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against INPP5A was raised in rabbit using the Recombinant Human Type I inositol 1,4,5-trisphosphate 5-phosphatase protein (1-409AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human colon cancer using INPP5A Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using INPP5A Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using INPP5A Antibody at dilution of 1:1003
| Cat.No | ADC-49726A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | INPP5A |
| Target Synonyms | 4, 5-trisphosphate 5-phophatase antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Type I inositol 1,4,5-trisphosphate 5-phosphatase protein (1-409AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14642 |
Uniprot Id
Q14642
Target Species
Human
Target Name
INPP5A
Target Full Name
Inositol polyphosphate-5-phosphatase A
Target Function
Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. Plays a crucial role in the survival of cerebellar Purkinje cells.
Target Subcellular Location
Cell membrane; Lipid-anchor. Cell projection, dendrite.
Target Protein Families
Inositol 1,4,5-trisphosphate 5-phosphatase type I family
Target Tissue Specificity
Predominantly expressed in heart, brain, and skeletal muscle. In brain; high level in Purkinje cells.
Target Research Area
Signal Transduction
Target Synonyms
4; 43 kDa inositol polyphosphate 5-phophatase; 5-trisphosphate 5-phosphatase; 5PTase; CTCL tumor antigen HD-CL-02; DKFZp434A1721; I5P1; I5P1_HUMAN; Inositol polyphosphate 5 phosphatase; inositol polyphosphate-5-phosphatase A; inositol trisphosphate-5-phosphatase; INPP5A; INPP5A inositol polyphosphate-5-phosphatase; InsP3 5-phosphatase; MGC116947; MGC116949; Type I inositol-1; type I inositol-1,4,5-trisphosphate 5-phophatase
Target Background
The protein encoded by this gene is a membrane-associated type I inositol 1, 4, 5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1, 4, 5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.
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