Rabbit anti-Human ITLN1 Polyclonal Antibody

Uniprot Id

Q8WWA0

Target Species

Human

Target Name

ITLN1

Target Full Name

Intelectin-1

Target Function

Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind human glycans. Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption.

Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Secreted.

Target Tissue Specificity

Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testi

Target Research Area

Cardiovascular

Target Synonyms

Endothelial lectin HL 1; Endothelial lectin HL-1; FLJ20022; Galactofuranose binding lectin; Galactofuranose-binding lectin; hIntL ; HL 1; HL-1; HL1 ; Intelectin ; Intelectin 1; Intelectin-1; Intestinal lactoferrin receptor; INTL ; ITLN; ITLN-1; ITLN1; ITLN1_HUMAN; LFR; Omentin; OTTHUMP00000027882

Target Background

Enables calcium ion binding activity; identical protein binding activity; and oligosaccharide binding activity. Involved in positive regulation of glucose import; positive regulation of protein phosphorylation; and protein homotrimerization. Located in extracellular exosome. Part of receptor complex.