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The antibody against KIRREL2 was raised in rabbit using the Recombinant Human Kin of IRRE-like protein 2 protein (21-219AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against KIRREL2 was raised in rabbit using the Recombinant Human Kin of IRRE-like protein 2 protein (21-219AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-19641A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KIRREL2 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Kin of IRRE-like protein 2 protein (21-219AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6UWL6 |
Uniprot Id
Q6UWL6
Target Species
Human
Target Name
KIRREL2
Target Full Name
Kin of IRRE-like protein 2
Target Function
May regulate basal insulin secretion.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Immunoglobulin superfamily
Target Tissue Specificity
Highly expressed in beta-cells of the pancreatic islets.
Target Synonyms
FILTRIN ; Kin of IRRE like 2 (Drosophila); Kin of IRRE-like protein 2; Kin of irregular chiasm like 2; Kin of irregular chiasm-like protein 2; KIRR2_HUMAN; KIRREL2; NEPH3 ; Nephrin like 3; nephrin-like gene 1; Nephrin-like protein 3; NLG1
Target Background
This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter.
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