Rabbit anti-Human KLC1 Polyclonal Antibody

Uniprot Id

Q07866

Target Species

Human

Target Name

KLC1

Target Full Name

Kinesin light chain 1

Target Function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

Target Subcellular Location

Cell projection, growth cone. Cytoplasmic vesicle. Cytoplasm, cytoskeleton.

Target Protein Families

Kinesin light chain family

Target Tissue Specificity

Found in a variety of tissues. Mostly abundant in brain and spine.

Target Synonyms

KLC; KNS2; KNS2A; Kinesin light chain 1 (KLC1)

Target Background

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.