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The antibody against KREMEN1 was raised in rabbit using the Recombinant Human Kremen protein 1 protein (180-380AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against KREMEN1 was raised in rabbit using the Recombinant Human Kremen protein 1 protein (180-380AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human skin tissue using KREMEN1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic tissue using KREMEN1 Antibody at dilution of 1:1002
| Cat.No | ADC-16303A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KREMEN1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Kremen protein 1 protein (180-380AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96MU8 |
Uniprot Id
Q96MU8
Target Species
Human
Target Name
KREMEN1
Target Full Name
Kremen protein 1
Target Function
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.
Target Involvement
Ectodermal dysplasia 13, hair/tooth type (ECTD13)
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Synonyms
AV002070; Dickkopf receptor; KREM1_HUMAN; KREMEN; Kremen protein 1; Kremen protein 1 precursor; Kremen1; Kringle coding gene marking the eye and the nose; Kringle containing protein marking the eye and the nose; Kringle containing transmembrane protein 1; Kringle containing transmembrane protein; Kringle domain containing transmembrane protein 1; Kringle domain-containing transmembrane protein 1; Kringle-containing protein marking the eye and the nose; KRM1; RP23 293J16.1
Target Background
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Mutations in this gene result in ectodermal dysplasia. This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2.
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