Rabbit anti-Human LDHB Polyclonal Antibody

Uniprot Id

P07195

Target Species

Human

Target Name

LDHB

Target Full Name

L-lactate dehydrogenase B chain

Target Involvement

Lactate dehydrogenase B deficiency (LDHBD)

Target Subcellular Location

Cytoplasm. Mitochondrion inner membrane; Peripheral membrane protein.

Target Protein Families

LDH/MDH superfamily, LDH family

Target Research Area

Metabolism

Target Synonyms

Epididymis secretory protein Li 281; HEL S 281; L lactate dehydrogenase B chain; L-lactate dehydrogenase B chain; Lactate Dehydrogenase B; Lactate dehydrogenase H chain; LDH B ; LDH H; LDH heart subunit; LDH-B; LDH-H; LDHB; LDHB_HUMAN; LDHBD; LDHH; Renal carcinoma antigen NY REN 46; Renal carcinoma antigen NY-REN-46; TRG-5; TRG5

Target Background

This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13.