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The antibody against LEMD2 was raised in rabbit using the Recombinant Human LEM domain-containing protein 2 protein (17-204AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against LEMD2 was raised in rabbit using the Recombinant Human LEM domain-containing protein 2 protein (17-204AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-06390A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LEMD2 |
| Target Synonyms | LEMD2; LEM domain-containing protein 2; hLEM2 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human LEM domain-containing protein 2 protein (17-204AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NC56 |
Uniprot Id
Q8NC56
Target Species
Human
Target Name
LEMD2
Target Full Name
LEM domain-containing protein 2
Target Function
Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope.; Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT. Required for myoblast differentiation involving regulation of ERK signaling.
Target Involvement
Cataract 46, juvenile-onset (CTRCT46)
Target Subcellular Location
Nucleus inner membrane; Multi-pass membrane protein. Note=Lamina-associated protein residing in the inner nuclear membrane (INM). Localized exclusively to the nuclear envelope, giving rise to a typical rim-like staining of the nuclear periphery.
Target Tissue Specificity
Ubiquitously expressed.
Target Synonyms
LEMD2; LEM domain-containing protein 2; hLEM2
Target Background
This gene encodes a LEM domain-containing transmembrane protein of the inner nuclear membrane. The protein is involved in nuclear structure organization and plays a role in cell signaling and differentiation. Mutations in this gene result in Cataract 46, juvenile-onset. Multiple transcript variants have been found for this gene.
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