Rabbit anti-Human LILRB4 Polyclonal Antibody

Uniprot Id

Q8NHJ6

Target Species

Human

Target Name

LILRB4

Target Full Name

Leukocyte immunoglobulin-like receptor subfamily B member 4

Target Function

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.

Target Tissue Specificity

Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.

Target Synonyms

CD85 antigen-like family member K; CD85k; HM18; ILT-3; ILT3; Immunoglobulin-like transcript 3; Leukocyte immunoglobulin like receptor subfamily B (with TM and ITIM domains) member 4; Leukocyte immunoglobulin-like receptor 5; Leukocyte immunoglobulin-like receptor subfamily B member 4; LILRB4; LILRB5; LIR-5; LIR5; LIRB4_HUMAN; Monocyte inhibitory receptor HM18

Target Background

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.