Rabbit anti-Human LIPH Polyclonal Antibody

Uniprot Id

Q8WWY8

Target Species

Human

Target Name

LIPH

Target Full Name

Lipase member H

Target Function

Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

Target Involvement

Hypotrichosis 7 (HYPT7); Woolly hair autosomal recessive 2 (ARWH2)

Target Subcellular Location

Secreted. Cell membrane; Peripheral membrane protein.

Target Protein Families

AB hydrolase superfamily, Lipase family

Target Tissue Specificity

Present in intestine (at protein level). Expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung and pancreas. Expressed at lower level in brain, spleen and heart. In hair, it is prominently expressed in hair follicles, including th

Target Synonyms

AH; ARWH2; LAH2; Lipase H; Lipase member H; LIPH; LIPH_HUMAN; LPD lipase related protein; LPD lipase-related protein; LPDLR; Membrane associated phosphatidic acid selective phospholipase A1 alpha; Membrane bound phosphatidic acid selective phospholipase A1; Membrane-associated phosphatidic acid-selective phospholipase A1-alpha; mPA PLA1; mPA-PLA1 alpha; MPAPLA1; OTTHUMP00000210343; OTTHUMP00000210344; Phospholipase A1 member B; PLA1B

Target Background

This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.