Rabbit anti-Human LMO1 Polyclonal Antibody

Uniprot Id

P25800

Target Species

Human

Target Name

LMO1

Target Full Name

Rhombotin-1

Target Function

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.

Target Involvement

A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expressed mainly in the central nervous. Low level of expression in other tissues including thymus.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

Cysteine rich protein TTG 1; Cysteine rich protein TTG1; Cysteine-rich protein TTG-1; LIM domain only 1; LIM domain only protein 1; LMO 1; LMO-1; lmo1; MGC116692; RBTN 1; RBTN1; RBTN1_HUMAN; RHOM 1; RHOM1; Rhombotin 1; Rhombotin-1; Rhombotin1; T cell translocation protein 1; T-cell translocation protein 1; TTG 1; TTG1

Target Background

This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described.