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The antibody against LRRFIP1 was raised in rabbit using the Recombinant Human Leucine-rich repeat flightless-interacting protein 1 protein (1-315AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against LRRFIP1 was raised in rabbit using the Recombinant Human Leucine-rich repeat flightless-interacting protein 1 protein (1-315AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human prostate cancer using LRRFIP1 Antibody at dilution of 1:100
Immunofluorescent analysis of Hela cells using LRRFIP1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
Immunohistochemistry of paraffin-embedded human spleen tissue using LRRFIP1 Antibody at dilution of 1:1003
| Cat.No | ADC-45783A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LRRFIP1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Leucine-rich repeat flightless-interacting protein 1 protein (1-315AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q32MZ4 |
Uniprot Id
Q32MZ4
Target Species
Human
Target Name
LRRFIP1
Target Full Name
Leucine-rich repeat flightless-interacting protein 1
Target Function
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
LRRFIP family
Target Tissue Specificity
Ubiquitously expressed.
Target Research Area
Transcription
Target Synonyms
FLAP 1; FLAP1; FLIIAP 1; FLIIAP1; GC binding factor 2; GC-binding factor 2; GCF 2; GCF2; HUFI 1; HUFI1; Leucine rich repeat (in FLII) interacting protein 1; Leucine rich repeat flightless interacting protein 1; Leucine-rich repeat flightless-interacting protein 1; LRR FLII interacting protein 1; LRR FLII-interacting protein 1; LRRF1_HUMAN; LRRFIP 1; Lrrfip1; MGC10947; MGC119738; MGC119739; NEDD8 conjugating enzyme; TAR RNA interacting protein; TAR RNA-interacting protein; Transcription factor 9 like; TRIP
Target Background
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and plasma membrane.
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