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The antibody against MAP1LC3C was raised in rabbit using the Synthetic peptide of Human MAP1LC3C as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against MAP1LC3C was raised in rabbit using the Synthetic peptide of Human MAP1LC3C as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-26447A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAP1LC3C |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human MAP1LC3C | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BXW4 |
Uniprot Id
Q9BXW4
Target Species
Human
Target Name
MAP1LC3C
Target Full Name
Microtubule-associated protein 1 light chain 3 gamma
Target Function
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins.
Target Subcellular Location
Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes.
Target Protein Families
ATG8 family
Target Tissue Specificity
Most abundant in placenta, lung and ovary.
Target Research Area
Cancer
Target Synonyms
ATG8J; Autophagy-related protein LC3 C; Autophagy-related ubiquitin-like modifier LC3 C; LC3 like protein 2; MAP1 light chain 3 like protein 2; MAP1 light chain 3 like protein 3; MAP1 light chain 3-like protein 3; MAP1A/MAP1B LC3 C; MAP1A/MAP1B light chain 3 C; MAP1LC3C; Microtubule-associated protein 1 light chain 3 gamma; Microtubule-associated proteins 1A/1B light chain 3C; MLP3C_HUMAN
Target Background
Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).
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