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The antibody against MAP3K1 was raised in rabbit using the Peptide sequence around phosphorylation site of threonine 1402(T-G-A(p)-G-F) derived from Human MAP3K1. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, WB, IHC.
The antibody against MAP3K1 was raised in rabbit using the Peptide sequence around phosphorylation site of threonine 1402(T-G-A(p)-G-F) derived from Human MAP3K1. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, WB, IHC.
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Western blot analysis of extracts from JK cells (Lane 2), using MAP3K1 (Phospho-Thr1400) Antibody. The lane on the left is treated with antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human brain tissue using MAP3K1 (Phospho-Thr1400) antibody (left)or the same antibody preincubated with blocking peptide (right).2
| Cat.No | ADC-42740A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAP3K1 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Peptide sequence around phosphorylation site of threonine 1402(T-G-A(p)-G-F) derived from Human MAP3K1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13233 |
Uniprot Id
Q13233
Target Species
Human
Target Name
MAP3K1
Target Full Name
Mitogen-activated protein kinase kinase kinase 1
Target Function
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
Target Involvement
46,XY sex reversal 6 (SRXY6)
Target Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
Target Synonyms
M3K1_HUMAN; MAP3K1; MAPK/ERK kinase kinase 1; MAPKKK1; MEK kinase 1; MEKK 1; Mekk; MEKK1; Mitogen activated protein kinase kinase kinase 1; Mitogen activated protein kinase kinase kinase 1; E3 ubiquitin protein ligase; Mitogen-activated protein kinase kinase kinase 1; SRXY6
Target Background
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.
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