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The antibody against MARCKS was raised in rabbit using the Human Marcks as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein A Purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against MARCKS was raised in rabbit using the Human Marcks as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein A Purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-48027A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MARCKS |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide |
| Purification Method | Protein A purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Human Marcks | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P29966 |
Uniprot Id
P29966
Target Species
Human
Target Name
MARCKS
Target Full Name
Myristoylated alanine-rich C-kinase substrate
Target Function
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Target Subcellular Location
Cytoplasm, cytoskeleton. Membrane; Lipid-anchor.
Target Protein Families
MARCKS family
Target Synonyms
80 kDa protein; 80K L; 80K L protein; 80K-L protein; 80KL; 81 kDa protein; light chain; light chain; MACS; MARCKS; MARCS; MARCS_HUMAN; MGC52672; myristoylated alanine rich C kinase substrate; Myristoylated alanine rich protein kinase C substrate (MARCKS; 80K L); Myristoylated alanine rich protein kinase C substrate; Myristoylated alanine-rich C-kinase substrate; Phosphomyristin; PKCSL; PRKCSL; protein kinase C substrate 80 kDa protein light chain; Protein kinase C substrate
Target Background
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
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