Rabbit anti-Human MAZ Polyclonal Antibody

Uniprot Id

P56270

Target Species

Human

Target Name

MAZ

Target Full Name

Myc-associated zinc finger protein

Target Function

Transcriptional regulator, potentially with dual roles in transcription initiation and termination.; Binds DNA and functions as a transcriptional activator. Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors.; Binds DNA and functions as a transcriptional activator. Inhibits MAZ isoform 1-mediated transcription.; Binds DNA and functions as a transcriptional activator.

Target Subcellular Location

Nucleus. Note=In brains of Alzheimer disease patients, present in a plaque-like structures.

Target Tissue Specificity

Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).; [Isoform 1]: Expressed in the heart, brain, placenta, lung, liver, skeletal muscle and weakly expressed in the kidney. Ex

Target Synonyms

MAZ; MAZ_HUMAN; MAZI; MYC associated zinc finger protein ; Myc-associated zinc finger protein; Pur-1; Pur1; Purine binding transcription factor ; Purine-binding transcription factor; SAF 1; SAF 2; SAF-1; SAF-2; SAF-3; Serum amyloid A activating factor 1; Serum amyloid A activating factor 2; Transcription factor Zif87; ZF87; Zif87; Zinc finger protein 801; Zinc finger protein, 87 kilodaltons; ZNF801

Target Background

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of gene expression; regulation of signal transduction; and transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus.