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The antibody against MCPH1 was raised in rabbit using the Recombinant Human Microcephalin protein (536-835AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC, IF.
The antibody against MCPH1 was raised in rabbit using the Recombinant Human Microcephalin protein (536-835AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human kidney tissue using MCPH1 Antibody at dilution of 1:100
Immunofluorescent analysis of Hela cells using MCPH1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-44368A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MCPH1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Microcephalin protein (536-835AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NEM0 |
Uniprot Id
Q8NEM0
Target Species
Human
Target Name
MCPH1
Target Full Name
Microcephalin
Target Function
Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
Target Involvement
Microcephaly 1, primary, autosomal recessive (MCPH1)
Target Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Tissue Specificity
Expressed in fetal brain, liver and kidney.
Target Synonyms
BRCT repeat inhibitor of TERT expression 1; BRIT 1; FLJ12847; Hypothetical protein FLJ12847; MCPH 1; MCPH1; MCPH1_HUMAN; MCT; Microcephalin 1; Microcephalin; Microcephaly primary autosomal recessive 1
Target Background
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described.
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