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The antibody against MECOM was raised in rabbit using the Recombinant Human Histone-lysine N-methyltransferase MECOM protein (534-632AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against MECOM was raised in rabbit using the Recombinant Human Histone-lysine N-methyltransferase MECOM protein (534-632AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-07650A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MECOM |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Histone-lysine N-methyltransferase MECOM protein (534-632AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q03112 |
Uniprot Id
Q03112
Target Species
Human
Target Name
MECOM
Target Full Name
Histone-lysine N-methyltransferase MECOM
Target Function
Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.; Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.
Target Involvement
Radioulnar synostosis with amegakaryocytic thrombocytopenia 2 (RUSAT2)
Target Subcellular Location
Nucleus. Nucleus speckle. Cytoplasm.
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