Rabbit anti-Human MEP1B Polyclonal Antibody

Uniprot Id

Q16820

Target Species

Human

Target Name

MEP1B

Target Full Name

Meprin A subunit beta

Target Function

Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Secreted.

Target Protein Families

Peptidase M12A family

Target Tissue Specificity

The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.

Target Synonyms

Endopeptidase 2 ; Endopeptidase-2; kinase splitting membranal proteinase; KSMP; Mep1b; MEP1B_HUMAN; Meprin 1 beta subunit; Meprin A beta; Meprin A beta subunit precursor; Meprin A subunit beta; Meprin B; N benzoyl L tyrosyl P amino benzoic acid hydrolase beta subunit; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta

Target Background

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.