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The antibody against MKLN1 was raised in rabbit using the Recombinant Human Muskelin protein (488-614AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against MKLN1 was raised in rabbit using the Recombinant Human Muskelin protein (488-614AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
| Cat.No | ADC-03770A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MKLN1 |
| Target Synonyms | intracellular mediator containing kelch motifs antibody; Muskelin antibody; TWA2 antibody; Two-hybrid-associated protein with Ranbpm 2 antibody, MKLN 1 antibody; Mkln1 antibody; MKLN1_HUMAN antibody; muskelin 1 | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Muskelin protein (488-614AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UL63 |
Uniprot Id
Q9UL63
Target Species
Human
Target Name
MKLN1
Target Full Name
Muskelin
Target Function
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.
Target Subcellular Location
Cytoplasm. Cytoplasm, cytosol. Nucleus, nucleoplasm. Cell projection, ruffle. Cytoplasm, cell cortex. Cell junction, synapse. Cell junction, synapse, postsynapse.
Target Synonyms
MKLN 1; Mkln1; MKLN1_HUMAN; muskelin 1, intracellular mediator containing kelch motifs ; Muskelin; TWA2; Two-hybrid-associated protein with Ranbpm 2
Target Background
Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).
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