Rabbit anti-Human MLX Polyclonal Antibody

Uniprot Id

Q9UH92

Target Species

Human

Target Name

MLX

Target Full Name

Max-like protein X

Target Function

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

Target Subcellular Location

[Isoform Alpha]: Cytoplasm.; [Isoform Beta]: Cytoplasm.; [Isoform Gamma]: Nucleus.

Target Tissue Specificity

Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung.

Target Synonyms

bHLHd13; BigMax protein; Class D basic helix-loop-helix protein 13; MAD7; Max like bHLHZip protein; Max like protein X; Max-like bHLHZip protein; Max-like protein X; MLX; MLX_HUMAN; MLXIP; MONDOA; MXD7; Protein BigMax; Protein Mlx; TCFL4; transcription factor like 4; Transcription factor like protein 4 ; Transcription factor-like protein 4

Target Background

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.