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The antibody against MPI was raised in rabbit using the Recombinant Human Mannose-6-phosphate isomerase protein (1-423AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against MPI was raised in rabbit using the Recombinant Human Mannose-6-phosphate isomerase protein (1-423AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human colon cancer using MPI Antibody at dilution of 1:1002
| Cat.No | ADC-17344A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MPI |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Mannose-6-phosphate isomerase protein (1-423AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P34949 |
Uniprot Id
P34949
Target Species
Human
Target Name
MPI
Target Full Name
Mannose-6-phosphate isomerase
Target Function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Target Involvement
Congenital disorder of glycosylation 1B (CDG1B)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Mannose-6-phosphate isomerase type 1 family
Target Tissue Specificity
Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.
Target Research Area
Signal Transduction
Target Synonyms
MI1; CDG1B; FLJ39201; Mannose 6 phosphate isomerase; Mannose-6-phosphate isomerase; MANNOSEPHOSPHATE ISOMERASE; MGC94106; MPI; MPI_HUMAN; Phosphohexomutase; phosphomannose isomerase 1; Phosphomannose isomerase; PMI
Target Background
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants.
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