Rabbit anti-Human MRPS22 Polyclonal Antibody

Uniprot Id

P82650

Target Species

Human

Target Name

MRPS22

Target Full Name

Small ribosomal subunit protein mS22

Target Involvement

Combined oxidative phosphorylation deficiency 5 (COXPD5)

Target Subcellular Location

Mitochondrion.

Target Protein Families

Mitochondrion-specific ribosomal protein mS22 family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

28S ribosomal protein S22; C3orf5; COXPD5; GIBT; GK002; mitochondrial; Mitochondrial ribosomal protein S22; MRP-S22; MRPS22; RPM S22; RPMS22; RT22_HUMAN; S22mt

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq.