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The antibody against MVK was raised in rabbit using the Synthesized peptide derived from the Internal region of Human MVK. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
The antibody against MVK was raised in rabbit using the Synthesized peptide derived from the Internal region of Human MVK. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
$167.00
Western Blot analysis of COLO205 cells using MVK Polyclonal Antibody
| Cat.No | ADC-38165A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MVK |
| Form | Liquid | Species Reactivity | Human, Monkey |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human MVK. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q03426 |
Uniprot Id
Q03426
Target Species
Human
Target Name
MVK
Target Full Name
Mevalonate kinase
Target Function
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
Target Involvement
Mevalonic aciduria (MEVA); Hyperimmunoglobulinemia D and periodic fever syndrome (HIDS); Porokeratosis 3, multiple types (POROK3)
Target Subcellular Location
Cytoplasm. Peroxisome.
Target Protein Families
GHMP kinase family, Mevalonate kinase subfamily
Target Synonyms
FLJ96772; KIME_HUMAN; LH receptor mRNA binding protein; LRBP; Mevalonate kinase 1; Mevalonate kinase; Mevalonic aciduria; MK; mvk; MVLK; POROK3
Target Background
This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants.
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