Rabbit anti-Human MZB1 Polyclonal Antibody

Uniprot Id

Q8WU39

Target Species

Human

Target Name

MZB1

Target Full Name

Marginal zone B- and B1-cell-specific protein

Target Function

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.; Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.

Target Subcellular Location

[Isoform 1]: Endoplasmic reticulum lumen. Secreted.; [Isoform 2]: Cytoplasm. Note=Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).

Target Protein Families

MZB1 family

Target Tissue Specificity

Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat.

Target Synonyms

MZB1; Caspase 2 binding protein; FLJ32987; HSPC190; Marginal zone B and B1 cell specific protein; Marginal zone B- and B1-cell-specific protein; MEDA 7; MEDA-7; Mesenteric estrogen dependent adipose 7; Mesenteric estrogen-dependent adipose 7; Mesenteric oestrogen dependent adipose gene 7; MGC29506; Mzb1; MZB1_HUMAN; PACAP; pERp1; Plasma cell-induced ER protein 1; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; Proapoptotic caspase adapter protein

Target Background

Involved in positive regulation of cell population proliferation. Located in cytoplasm and extracellular region.