Rabbit anti-Human NAT2 Polyclonal Antibody

The antibody against NAT2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 171-290 of human NAT2 (NP_000006.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-12122A

Number

Cat.No	ADA-12122A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	NAT2
Target Synonyms	AAC2; PNAT; NAT-2; NAT2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse heart, Mouse kidney, 293T, Mouse liver	Application	ELISA, WB, IHC-P

Cat.No

ADA-12122A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

NAT2

Target Synonyms

AAC2; PNAT; NAT-2; NAT2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse heart, Mouse kidney, 293T, Mouse liver

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 171-290 of human NAT2 (NP_000006.2).	Target Species	Human
Immunogen Sequence	TNKEFLNSHLLPKKKHQKIYLFTLEPRTIEDFESMNTYLQTSPTSSFITTSFCSLQTPEGVYCLVGFILTYRKFNYKDNTDLVEFKTLTEEEVEEVLRNIFKISLGRNLVPKPGDGSLTI	Uniprot ID	P11245

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 171-290 of human NAT2 (NP_000006.2).

Target Species

Human

Immunogen Sequence

TNKEFLNSHLLPKKKHQKIYLFTLEPRTIEDFESMNTYLQTSPTSSFITTSFCSLQTPEGVYCLVGFILTYRKFNYKDNTDLVEFKTLTEEEVEEVLRNIFKISLGRNLVPKPGDGSLTI

Uniprot ID

P11245

Background Information

Uniprot Id

P11245
Target Species

Human
Target Name

NAT2
Target Full Name

Arylamine N-acetyltransferase 2
Target Function

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Target Subcellular Location

Cytoplasm.
Target Protein Families

Arylamine N-acetyltransferase family
Target Research Area

Signal Transduction
Target Synonyms

AAC2; ARY2_HUMAN; Arylamide acetylase 2 (N-acetyltransferase 2, isoniazid inactivation); Arylamide acetylase 2; Arylamine N-acetyltransferase 2; HGNC:7646; N-acetyltransferase 2 (arylamine N-acetyltransferase); N-acetyltransferase type 2; NAT-2; NAT2; PNAT; Polymorphic arylamine N-acetyltransferase
Target Background

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2).

Rabbit anti-Human NAT2 Polyclonal Antibody

Specifications

Immunogen Information

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