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The antibody against NCF1 was raised in rabbit using the Synthesized non-phosphopeptide derived from Human Neutrophil Cytosol Factor 1 around the phosphorylation site of serine 304 (R-S-S(p)-I-R). as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
The antibody against NCF1 was raised in rabbit using the Synthesized non-phosphopeptide derived from Human Neutrophil Cytosol Factor 1 around the phosphorylation site of serine 304 (R-S-S(p)-I-R). as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
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Immunofluorescence analysis of HeLa cells, using Neutrophil Cytosol Factor 1 (Ab-304) antibody.
Western blot analysis of extracts from colo cells, using Neutrophil Cytosol Factor 1 (Ab-304) antibody.2
Western blot analysis of extracts from HepG2 cells (Lane 2) and Jurket cells (Lane 3), using Neutrophil Cytosol Factor 1 (Ab-304) antiobdy. The lane on the left is treated with synthesized peptide.3
| Cat.No | ADC-42586A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NCF1 |
| Target Synonyms | chronic granulomatous disease | Form | Liquid |
| Species Reactivity | Human | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized non-phosphopeptide derived from Human Neutrophil Cytosol Factor 1 around the phosphorylation site of serine 304 (R-S-S(p)-I-R). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P14598 |
Uniprot Id
P14598
Target Species
Human
Target Name
NCF1
Target Full Name
Neutrophil cytosol factor 1
Target Function
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Target Involvement
Granulomatous disease, chronic, cytochrome-b-positive 1, autosomal recessive (CGD1)
Target Subcellular Location
Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side.
Target Tissue Specificity
Detected in peripheral blood monocytes and neutrophils (at protein level).
Target Synonyms
47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NADPH oxidase organizer 2; NCF 47K; NCF-1; NCF-47K; Ncf1; NCF1_HUMAN; Neutrophil cytosol factor 1; Neutrophil cytosolic factor 1; neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1); Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox organizing protein 2; Nox-organizing protein 2; NOXO2; p47 phox; p47-phox; SH3 and PX domain containing protein 1A; SH3 and PX domain-containing protein 1A; SH3PXD1A
Target Background
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.
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