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The antibody against NELFCD was raised in rabbit using the Recombinant Human Negative elongation factor C/D protein (346-590AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against NELFCD was raised in rabbit using the Recombinant Human Negative elongation factor C/D protein (346-590AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-40221A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NELFCD |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Negative elongation factor C/D protein (346-590AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IXH7 |
Uniprot Id
Q8IXH7
Target Species
Human
Target Name
NELFCD
Target Full Name
Negative elongation factor C/D
Target Function
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
Target Subcellular Location
Nucleus.
Target Protein Families
NELF-D family
Target Tissue Specificity
Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.
Target Synonyms
TH1; TH1L; NELF-C; NELF-D; HSPC130; NELFCD
Target Background
The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.
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