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The antibody against NKX6-1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Nkx-6.1. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against NKX6-1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Nkx-6.1. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
| Cat.No | ADC-34883A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NKX6-1 |
| Target Synonyms | A antibody; NK homeobox, A antibody; NK6 homeobox 1 antibody; NK6 transcription factor homolog A antibody; NK6 transcription factor related, family 6, Homeobox protein NK-6 homolog A antibody; Homeobox protein Nkx-6.1 antibody; NK homeo box, locus 1 (Drosophila) antibody; NKX6-1 antibody; NKX6.1 antibody; NKX61 antibody; NKX61_HUMAN antibody; NKX6A antibody, locus 1 antibody; NK6 transcription factor related, member A antibody; NK homeobox (Drosophila) | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human Nkx-6.1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P78426 |
Uniprot Id
P78426
Target Species
Human
Target Name
NKX6-1
Target Full Name
Homeobox protein Nkx-6.1
Target Function
Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Pancreatic beta cells.
Target Synonyms
Homeobox protein NK-6 homolog A; Homeobox protein Nkx-6.1; NK homeo box, family 6, member A ; NK homeobox (Drosophila), family 6, A; NK homeobox, family 6, A ; NK6 homeobox 1; NK6 transcription factor homolog A ; NK6 transcription factor related, locus 1 ; NK6 transcription factor related, locus 1 (Drosophila); NKX6-1; NKX6.1; NKX61; NKX61_HUMAN; NKX6A
Target Background
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].
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