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The antibody against OSGEP was raised in rabbit using the Recombinant Human Probable tRNA N6-adenosine threonylcarbamoyltransferase protein (1-335AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against OSGEP was raised in rabbit using the Recombinant Human Probable tRNA N6-adenosine threonylcarbamoyltransferase protein (1-335AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-17124A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OSGEP |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Probable tRNA N6-adenosine threonylcarbamoyltransferase protein (1-335AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NPF4 |
Uniprot Id
Q9NPF4
Target Species
Human
Target Name
OSGEP
Target Full Name
tRNA N6-adenosine threonylcarbamoyltransferase
Target Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
KAE1 / TsaD family
Target Tissue Specificity
Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas.
Target Research Area
others
Target Synonyms
FLJ20411; GCPL-1; GCPL1; hOSGEP; KAE1; O sialoglycoprotein endopeptidase; OSGEP; OSGEP_HUMAN; OSGEP1; Pasteurella haemolytica metalloprotease homolog with glycoprotein substrates/gpc-like protein 1; Probable O sialoglycoprotein endopeptidase; Probable tRNA threonylcarbamoyladenosine biosynthesis protein osgep; PRSMG1; Prsmg1/Gcpl1; t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep
Target Background
Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytoplasm; nuclear speck; and plasma membrane. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 3.
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