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The antibody against PAPPA was raised in rabbit using the Recombinant Human Pappalysin-1 protein (95-302AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against PAPPA was raised in rabbit using the Recombinant Human Pappalysin-1 protein (95-302AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human ovarian cancer using PAPPA Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using PAPPA Antibody at dilution of 1:1002
| Cat.No | ADC-50805A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PAPPA |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Pappalysin-1 protein (95-302AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13219 |
Uniprot Id
Q13219
Target Species
Human
Target Name
PAPPA
Target Full Name
Pappalysin-1
Target Function
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Target Subcellular Location
Secreted.
Target Protein Families
Peptidase M43B family
Target Tissue Specificity
High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium
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