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The antibody against Capsid protein VP1 was raised in rabbit using the Recombinant Human parvovirus B19 Capsid protein VP1 protein (228-781AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against Capsid protein VP1 was raised in rabbit using the Recombinant Human parvovirus B19 Capsid protein VP1 protein (228-781AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-44889A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Capsid protein VP1 |
| Target Synonyms | Minor capsid protein VP1 antibody; EC 3.1.1.4 antibody; Coat protein VP1 antibody | Form | Liquid |
| Species Reactivity | Human parvovirus B19 | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human parvovirus B19 Capsid protein VP1 protein (228-781AA) | Target Species | Human parvovirus B19 |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P07299 |
Uniprot Id
P07299
Target Species
Human parvovirus B19
Target Function
Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 20 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Binds to erythroid progenitor cells expressing high levels of P antigen and uses host ITGA5-ITGB1 and XRCC5/Ku80 autoantigen as coreceptors on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region. The additional N-terminal region of isoform Minor capsid protein VP1, called VP1u, may serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.
Target Subcellular Location
[Isoform Minor capsid protein VP1]: Virion. Host nucleus. Host cytoplasm.; [Isoform Major capsid protein VP2]: Virion. Host nucleus. Host cytoplasm.
Target Protein Families
Parvoviridae capsid protein family
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