Rabbit anti-Human PAX4 Polyclonal Antibody

Uniprot Id

O43316

Target Species

Human

Target Name

PAX4

Target Full Name

Paired box protein Pax-4

Target Function

Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.

Target Involvement

Diabetes mellitus, non-insulin-dependent (NIDDM); Diabetes mellitus, insulin-dependent (IDDM); Diabetes mellitus, ketosis-prone (KPD); Maturity-onset diabetes of the young 9 (MODY9)

Target Subcellular Location

Nucleus.

Target Protein Families

Paired homeobox family

Target Synonyms

KPD; MGC129960; MODY9; Paired box 4; Paired box gene 4; paired box homeotic gene 4; Paired box protein Pax-4; Paired domain gene 4; Pax4; PAX4_HUMAN

Target Background

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.