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The antibody against PBXIP1 was raised in rabbit using the Recombinant Human Pre-B-cell leukemia transcription factor-interacting protein 1 protein (361-600AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against PBXIP1 was raised in rabbit using the Recombinant Human Pre-B-cell leukemia transcription factor-interacting protein 1 protein (361-600AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-24151A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PBXIP1 |
| Target Synonyms | PBXIP1 antibody; HPIPPre-B-cell leukemia transcription factor-interacting protein 1 antibody; Hematopoietic PBX-interacting protein antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Pre-B-cell leukemia transcription factor-interacting protein 1 protein (361-600AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96AQ6 |
Uniprot Id
Q96AQ6
Target Species
Human
Target Name
PBXIP1
Target Full Name
Pre-B-cell leukemia transcription factor-interacting protein 1
Target Function
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
Target Subcellular Location
Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).
Target Tissue Specificity
Expressed in early hematopoietic precursors.
Target Synonyms
PBXIP1; HPIPPre-B-cell leukemia transcription factor-interacting protein 1; Hematopoietic PBX-interacting protein
Target Background
The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined.
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