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The antibody against PDE11A was raised in rabbit using the Recombinant Human Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A protein (42-190AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against PDE11A was raised in rabbit using the Recombinant Human Dual 3′,5′-cyclic-AMP and -GMP phosphodiesterase 11A protein (42-190AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human tonsil tissue using PDE11A Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using PDE11A Antibody at dilution of 1:1002
Immunofluorescent analysis of HepG2 cells using PDE11A Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-10078A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDE11A |
| Target Synonyms | 5'-cyclic-AMP and -GMP phosphodiesterase 11A antibody; pde11 antibody; PDE11_HUMAN antibody; pde11a antibody; PDE11A1 antibody; pde11a2 antibody; Phosphodiesterase 11A antibody; PPNAD2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A protein (42-190AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HCR9 |
Uniprot Id
Q9HCR9
Target Species
Human
Target Name
PDE11A
Target Full Name
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Target Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Target Involvement
Primary pigmented nodular adrenocortical disease 2 (PPNAD2)
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
Cyclic nucleotide phosphodiesterase family
Target Tissue Specificity
Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is ex
Target Synonyms
5''-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A; cGMP phosphodiesterase 11A; Cyclic nucleotide phosphodiesterase 11A; Dual 3''; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; pde11; PDE11_HUMAN; pde11a; PDE11A1; pde11a2; Phosphodiesterase 11A; PPNAD2
Target Background
The 3', 5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3', 5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
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