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The antibody against PDE4B was raised in rabbit using the Recombinant Human cAMP-specific 3',5'-cyclic phosphodiesterase 4B protein (27-215AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against PDE4B was raised in rabbit using the Recombinant Human cAMP-specific 3′,5′-cyclic phosphodiesterase 4B protein (27-215AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human lung tissue using PDE4B Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human glioma using PDE4B Antibody at dilution of 1:1002
| Cat.No | ADC-08810A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDE4B |
| Target Synonyms | 5''-cyclic phosphodiesterase 4B antibody; cAMP-specific 3'' antibody; cAMP-specific 3', cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila) antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human cAMP-specific 3',5'-cyclic phosphodiesterase 4B protein (27-215AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q07343 |
Uniprot Id
Q07343
Target Species
Human
Target Name
PDE4B
Target Full Name
3',5'-cyclic-AMP phosphodiesterase 4B
Target Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Target Protein Families
Cyclic nucleotide phosphodiesterase family, PDE4 subfamily
Target Tissue Specificity
Expressed in brain, heart, lung and skeletal muscle.
Target Synonyms
DPDE4; PDEIVB; PDE4B
Target Background
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.
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