Rabbit anti-Human PEG10 Polyclonal Antibody

Uniprot Id

Q86TG7

Target Species

Human

Target Name

PEG10

Target Full Name

Retrotransposon-derived protein PEG10

Target Function

Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ACVRL1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ACVRL1. Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.

Target Subcellular Location

Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ACVRL1.

Target Tissue Specificity

Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level).

Target Synonyms

AA407948; Edr; Embryonal carcinoma differentiation regulated; Embryonal carcinoma differentiation-regulated protein; HB 1; HB1; KIAA1051; Mammalian retrotransposon-derived protein 2; Mar2; Mart2; MEF3 like 1; MEF3-like protein 1; MEF3L; MEF3L1; MyEF 3; Myelin expression factor 3-like protein 1; Paternally expressed 10; Paternally expressed gene 10 ORF1; Paternally expressed gene 10 protein; Peg10; PEG10 protein; PEG10_HUMAN; Putative uncharacterized protein PEG10; Retrotransposon gag domain containing 3; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Retrotransposon-derived protein PEG10; RGAG3; Ty3/Gypsy-like protein

Target Background

This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene.