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The antibody against PHACTR4 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human PHACTR4. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against PHACTR4 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human PHACTR4. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
| Cat.No | ADC-34069A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PHACTR4 |
| Target Synonyms | Phactr4 antibody; PHAR4_HUMAN antibody; Phosphatase and actin regulator 4 antibody; PRO2963 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human PHACTR4. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IZ21 |
Uniprot Id
Q8IZ21
Target Species
Human
Target Name
PHACTR4
Target Full Name
Phosphatase and actin regulator 4
Target Function
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway.
Target Subcellular Location
Cytoplasm. Cell projection, lamellipodium.
Target Protein Families
Phosphatase and actin regulator family
Target Synonyms
Phactr4; PHAR4_HUMAN; Phosphatase and actin regulator 4; PRO2963
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