Rabbit anti-Human PHLDA3 Polyclonal Antibody

The antibody against PHLDA3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-127 of human PHLDA3 (NP_036528.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03180A

Number

Cat.No	ADA-03180A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PHLDA3
Target Synonyms	TIH1; PHLDA3	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	A-431, SKOV3	Application	ELISA, WB

Cat.No

ADA-03180A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PHLDA3

Target Synonyms

TIH1; PHLDA3

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

A-431, SKOV3

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-127 of human PHLDA3 (NP_036528.1).	Target Species	Human
Immunogen Sequence	MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSLGTGTLVS	Uniprot ID	Q9Y5J5

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-127 of human PHLDA3 (NP_036528.1).

Target Species

Human

Immunogen Sequence

MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSLGTGTLVS

Uniprot ID

Q9Y5J5

Background Information

Uniprot Id

Q9Y5J5
Target Species

Human
Target Name

PHLDA3
Target Full Name

Pleckstrin homology-like domain family A member 3
Target Function

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
Target Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein.
Target Protein Families

PHLDA3 family
Target Tissue Specificity

Widely expressed with lowest expression in liver and spleen.
Target Synonyms

PHLA3_HUMAN; PHLDA 3; phlda3; Pleckstrin homology like domain family A member 2; Pleckstrin homology like domain family A member 3; Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1; TDAG51/Ipl homologue 1; TIH 1; TIH1
Target Background

Enables phosphatidylinositol phosphate binding activity and phosphatidylinositol-3, 4-bisphosphate binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of protein kinase B signaling; and positive regulation of apoptotic process. Located in plasma membrane.

Rabbit anti-Human PHLDA3 Polyclonal Antibody

Specifications

Immunogen Information

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