Rabbit anti-Human PKD2L1 Polyclonal Antibody

Uniprot Id

Q9P0L9

Target Species

Human

Target Name

PKD2L1

Target Full Name

Polycystin-2-like protein 1

Target Function

Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration. The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription. Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells. The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again. May play a role in the perception of carbonation taste. May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH.

Target Subcellular Location

Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle.

Target Protein Families

Polycystin family

Target Tissue Specificity

Detected in taste bud cells in fungiform papillae (at protein level). Ubiquitous. Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. Isoform 4 appears to be expressed only in transformed lymphoblasts.

Target Synonyms

B830002B15; BC046386; PCL; PK2L1; PK2L1_HUMAN; PKD2L; PKD2L1; PKDL; Polycystic kidney disease 2 like 1; Polycystic kidney disease 2 like 1 protein; Polycystic kidney disease 2-like 1 protein; Polycystin L; Polycystin-2 homolog; Polycystin-2L1; Polycystin-L; Polycystin-L1; Transient receptor potential cation channel subfamily P member 3; TRPP3