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The antibody against PLAA was raised in rabbit using the Recombinant Human Phospholipase A-2-activating protein (536-795AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against PLAA was raised in rabbit using the Recombinant Human Phospholipase A-2-activating protein (536-795AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human lung cancer using PLAA Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human endometrial cancer using PLAA Antibody at dilution of 1:1002
| Cat.No | ADC-16265A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PLAA |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Phospholipase A-2-activating protein (536-795AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y263 |
Uniprot Id
Q9Y263
Target Species
Human
Target Name
PLAA
Target Full Name
Phospholipase A-2-activating protein
Target Function
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
Target Involvement
Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA)
Target Subcellular Location
Nucleus. Cytoplasm. Cell junction, synapse.
Target Protein Families
WD repeat PLAP family
Target Synonyms
DOA1; PLAP; PLA2P; NDMSBA; PLAA
Target Background
Predicted to enable ubiquitin binding activity. Involved in cellular response to lipopolysaccharide; macroautophagy; and positive regulation of phospholipase A2 activity. Located in cytoplasm; extracellular exosome; and nucleus.
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