Rabbit anti-Human Placental lactogen (CSH1) Polyclonal Antibody

Uniprot Id

P0DML2

Target Species

Human

Target Name

CSH1

Target Full Name

Chorionic somatomammotropin hormone 1

Target Function

Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.

Target Subcellular Location

Secreted.

Target Protein Families

Somatotropin/prolactin family

Target Synonyms

PL; CSA; CS-1; CSMT; GHB3; hCS-1; hCS-A; Placental lactogen (CSH1)

Target Background

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.