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The antibody against PLCB1 was raised in rabbit using the Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 protein (781-896AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against PLCB1 was raised in rabbit using the Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 protein (781-896AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human glioma using PLCB1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using PLCB1 Antibody at dilution of 1:1002
Immunofluorescent analysis of MCF-7 cells using PLCB1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-11627A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PLCB1 |
| Target Synonyms | 1 phosphatidylinositol 4, 5 bisphosphate phosphodiesterase beta 1 antibody; 1-phosphatidyl-D-myo-inositol-4 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 protein (781-896AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NQ66 |
Uniprot Id
Q9NQ66
Target Species
Human
Target Name
PLCB1
Target Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Target Function
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier.
Target Involvement
Epileptic encephalopathy, early infantile, 12 (EIEE12)
Target Subcellular Location
Nucleus membrane. Cytoplasm.
Target Synonyms
1 phosphatidylinositol 4,5 bisphosphate phosphodiesterase beta 1; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4; 1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase beta-1; EIEE12; Inositoltrisphosphohydrolase; Monophosphatidylinositol phosphodiesterase; Phosphb; Phosphoinositidase C; Phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta 1; Phosphoinositide phospholipase C-beta-1; Phospholipase C beta 1 (phosphoinositide-specific); Phospholipase C I; Phospholipase C-beta-1; Phospholipase C-I; PI PLC; PLC 1; PLC beta 1; PLC I; PLC-154; PLC-beta-1; PLC-I; PLC154; Plcb; Plcb1; Plcb1 protein ; PLCB1_HUMAN; PLCbeta1; Triphosphoinositide phosphodiesterase
Target Background
The protein encoded by this gene catalyzes the formation of inositol 1, 4, 5-trisphosphate and diacylglycerol from phosphatidylinositol 4, 5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.
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