Rabbit anti-Human PLCD4 Polyclonal Antibody

Uniprot Id

Q9BRC7

Target Species

Human

Target Name

PLCD4

Target Full Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

Target Function

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.; Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3.

Target Subcellular Location

Membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.

Target Tissue Specificity

Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells.

Target Research Area

Signal Transduction

Target Synonyms

1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase delta 4; 1-phosphatidylinositol 4; 1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase delta-4; hPLCD4; MGC12837; Phosphoinositide phospholipase C delta 4; Phosphoinositide phospholipase C-delta-4; Phospholipase C delta 4; Phospholipase C-delta-4; PLC delta 4; PLC delta4; PLC-delta-4; PLCD4; PLCD4_HUMAN

Target Background

This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4, 5-bisphosphate into two intracellular second messengers, inositol 1, 4, 5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer.