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The antibody against PNLIP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 166-465 of human PNLIP (NP_000927.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against PNLIP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 166-465 of human PNLIP (NP_000927.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-03052A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PNLIP |
| Target Synonyms | PL; PTL; PNLIPD; PNLIP | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse liver, Mouse pancreas | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 166-465 of human PNLIP (NP_000927.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P16233 | Immunogen Sequence |
Uniprot Id
P16233
Target Species
Human
Target Name
PNLIP
Target Full Name
Pancreatic triacylglycerol lipase
Target Function
Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
Target Involvement
Pancreatic lipase deficiency (PNLIPD)
Target Subcellular Location
Secreted.
Target Protein Families
AB hydrolase superfamily, Lipase family
Target Synonyms
lipase, pancreatic; LIPP_HUMAN; Pancreatic lipase; Pancreatic triacylglycerol lipase; PL; PNLIP; PNLIPD; PTL; Triacylglycerol acylhydrolase
Target Background
This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea.
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