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The antibody against POLE was raised in rabbit using the Recombinant Human DNA polymerase epsilon catalytic subunit A protein (1175-1311AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against POLE was raised in rabbit using the Recombinant Human DNA polymerase epsilon catalytic subunit A protein (1175-1311AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
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| Cat.No | ADC-08978A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | POLE |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | HRP conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human DNA polymerase epsilon catalytic subunit A protein (1175-1311AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q07864 |
Uniprot Id
Q07864
Target Species
Human
Target Name
POLE
Target Full Name
DNA polymerase epsilon catalytic subunit A
Target Function
Catalytic component of the DNA polymerase epsilon complex. Participates in chromosomal DNA replication. Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication. Involved in DNA synthesis during DNA repair. Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation.
Target Involvement
Colorectal cancer 12 (CRCS12); Facial dysmorphism, immunodeficiency, livedo, and short stature (FILS)
Target Subcellular Location
Nucleus.
Target Protein Families
DNA polymerase type-B family
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