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The antibody against PRLR was raised in rabbit using the Recombinant Human Prolactin receptor protein (330-548AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against PRLR was raised in rabbit using the Recombinant Human Prolactin receptor protein (330-548AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human kidney tissue using PRLR Antibody at dilution of 1:100
| Cat.No | ADC-10856A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PRLR |
| Target Synonyms | PRLR; Prolactin receptor; PRL-R | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Prolactin receptor protein (330-548AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P16471 |
Uniprot Id
P16471
Target Species
Human
Target Name
PRLR
Target Full Name
Prolactin receptor
Target Function
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Target Involvement
Multiple fibroadenomas of the breast (MFAB); Hyperprolactinemia (HPRL)
Target Subcellular Location
Membrane; Single-pass type I membrane protein.; [Isoform 7]: Secreted.
Target Protein Families
Type I cytokine receptor family, Type 1 subfamily
Target Tissue Specificity
Expressed in breast, placenta, kidney, liver and pancreas.
Target Synonyms
PRLR; Prolactin receptor; PRL-R
Target Background
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer.
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