Rabbit anti-Human PTPN3 Polyclonal Antibody

Uniprot Id

P26045

Target Species

Human

Target Name

PTPN3

Target Full Name

Tyrosine-protein phosphatase non-receptor type 3

Target Function

May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Target Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.

Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class subfamily

Target Synonyms

cytoskeletal-associated protein tyrosine phosphatase; protein tyrosine phosphatase H1; protein tyrosine phosphatase non-receptor type 3; Protein-tyrosine phosphatase H1; PTN3_HUMAN; PTP-H1; PTPH1; PTPN3; Tyrosine-protein phosphatase non-receptor type 3

Target Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.