Rabbit anti-Human PTPN4 Polyclonal Antibody

Uniprot Id

P29074

Target Species

Human

Target Name

PTPN4

Target Full Name

Tyrosine-protein phosphatase non-receptor type 4

Target Function

Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway. May act at junctions between the membrane and the cytoskeleton.

Target Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm.

Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class subfamily

Target Synonyms

MEG; megakaryocyte phosphatase; megakaryocyte protein-tyrosine phosphatase; Protein tyrosine phosphatase MEG1; Protein tyrosine phosphatase; megakaryocyte; protein tyrosine phosphatase; non-receptor type 4 (megakaryocyte); Protein-tyrosine phosphatase MEG1; PTN4; PTN4_HUMAN; PTPase MEG1; PTPase-MEG1; PTPMEG; PTPMEG1; Ptpn4; Tyrosine protein phosphatase non receptor type 4; Tyrosine-protein phosphatase non-receptor type 4

Target Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.