Rabbit anti-Human PTPRO Polyclonal Antibody

Uniprot Id

Q16827

Target Species

Human

Target Name

PTPRO

Target Full Name

Receptor-type tyrosine-protein phosphatase O

Target Function

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function.

Target Involvement

Nephrotic syndrome 6 (NPHS6)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Protein-tyrosine phosphatase family, Receptor class 3 subfamily

Target Tissue Specificity

Glomerulus of kidney. Also detected in brain, lung and placenta.

Target Synonyms

FMI; GLEPP 1; Glomerular epithelial protein 1; hPTP-J; Pancreatic carcinoma phosphatase 2; PCP-2; PCP2; Phosphotyrosine phosphatase U2; Protein tyrosine phosphatase PTP U2; Protein tyrosine phosphatase PTPU2; Protein tyrosine phosphatase receptor type O; Protein tyrosine phosphatase U2; Protein-tyrosine phosphatase J; Protein-tyrosine phosphatase pi; Protein-tyrosine phosphatase receptor omicron; PTP pi; PTP U2; PTP-J; PTP-RO; PTP-U2; PTPase U2; PTPRO; PTPRO_HUMAN; PTPROt; PTPU 2; PTPU2; R-PTP-O; R-PTP-psi; Receptor type protein tyrosine phosphatase O; Receptor type tyrosine protein phosphatase O; Receptor-type protein-tyrosine phosphatase psi; Receptor-type tyrosine-protein phosphatase O; Receptor-type tyrosine-protein phosphatase U

Target Background

This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer.